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 Mesotherapy involves a series of chemical injections with short, fine needles that target the middle layer of skin that uses pharmaceutical and homeopathic preparations, plant extracts, vitamins, and other ingredients into subcutaneous fat. It was first developed in France in 1952 by Dr. Michel Pistor, as a treatment for sports injuries and a way to improve circulation. Mesotherapy is a nonsurgical, permanent method for fat removal, body contouring and is also used for hair loss and skin ageing.